MS Exchange NDR

1. NDR MS Exchange

We recently installed Small Business Server and, as part
of the package, Exchange 2000 Server.  All local network
traffic is being handled by exchange server as well as
inbound mail from external parties.  However, we continue
to have messages sent from internal parties to external
parties return NDR's indicating that the operation timed
out.  This does not happen on every attempt, only some.  
And, it is not the case that some workstations have
problems and some do not.  All have the problem.

Does anyone have any idea of a possible solution or at
least where I can start looking for the problem?

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