I had the same problem with CA E-trust Inoculate anti-virus as the cause.
Actually, it was probably a specific signature file update. Uninstalling
E-trust would make the problem disappear, but it would come back after a
reinstall. Once they issued a new signature update, there was no problem
after reinstalling with that update. (Although they deny that the update
could have caused the problem).
> I had the exact same problem after upgrading to SP2. My problem was with
> the Mcafee program I was running at the time. The version I was using was
> not compatible. I upgraded to the most recent version and my problem was
> resolved. I have also heard of this same issue for admins running Trend
> Micro AV as well.
> hope this helps.
> > I have an Exchange 2000 Server SP2 running on a Windows
> > 2000 Server SP2. Task Manager showed that the store.exe
> > was causing 100% CPU usage. The "kill" command had to be
> > used to stop store.exe as the IS couldn't be stopped from
> > the Services applet.
> > I set the Public and Mailbox stored not to mount when the
> > Info Store starts, rebooted the server and ths IS service
> > starts fine and CPU usage is normal. As soon as I tried to
> > mount any of the stores (Mailbox or Public) the CPU usage
> > shot up to 100%.
> > Isinteg and eseutil have both been run to check/repair
> > databases - databases were all consistent.
> > I would be very grateful for any suggestions in resolving
> > this issue.
> > Thank you.
> > Regards
> > Mitesh Shah